Position summary:

In this role, you will lead the design, execution, and interpretation of in vitro and in vivo DMPK studies, directly driving our groundbreaking drug development programs. You’ll develop and implement DMPK strategies, collaborate closely with cross-functional teams including Chemistry, Pharmacology, Toxicology, and Pathology, and manage external partnerships to ensure the success of our projects. This is a unique chance to shape the DMPK function at Neomorph, contributing directly to the development of novel therapies for unmet medical needs. 

What You’ll Do: 

• Lead and Strategize:  Design, execute, and interpret in vitro and in vivo DMPK studies to support our cutting-edge drug development programs. Develop and implement DMPK strategies for early preclinical drug discovery and development. Lead the implementation of in-house capabilities as we build our development organization. 

• Collaborate:  Work hand-in-hand with cross-functional groups including chemistry, pharmacology, toxicology, pathology, CMC and early clinical to integrate DMPK data seamlessly into our projects. 

• Provide Expertise:  Share your knowledge in ADME (Absorption, Distribution, Metabolism, and Excretion), pharmacokinetics, and bioanalytical methods within our cross-functional project teams. 

• Manage Partnerships:  Oversee external CROs (Contract Research Organizations) for DMPK studies, ensuring high quality protocol development, study monitoring, and data review and interpretation. 

• Communicate:  Prepare and present DMPK data and reports to project teams, senior management, and external stakeholders. Author and review relevant sections of regulatory documents. 

• Stay Current and Innovate:  Keep up with the latest advancements in the DMPK field and bring new technologies and methodologies to our projects.  

Required qualifications:

• PhD in Pharmacokinetics, Drug Metabolism, Pharmaceutical Sciences, or a related field with 12 years, MS with 15+ years or BS with 18+ years of relevant experience.

• Significant industry experience in DMPK with a strong focus on early preclinical drug development. Excellent analytical skills with demonstrated expertise in clinical candidate selection and development of small molecules. 
• Knowledgeable:  Deep understanding of ADME, pharmacokinetics, and bioanalytical techniques. 

• Versatile and adaptable:  Proven experience in a small company or startup environment. Ability to thrive in a fast-paced environment. Able to juggle multiple projects and adapt to changing priorities seamlessly. 

• Innovative:  Ability to design, execute, and interpret DMPK studies creatively and effectively. Willing and enthusiastic to build internal DMPK team as we grow. 

• Collaborative:  Excellent communication and interpersonal skills, thriving in a fast-paced, collaborative environment. 

• Organized:  Highly organized and detail-oriented, with exceptional problem-solving and communication skills. 

Preferred qualifications:

• Proficiency in Phoenix WinNonlin highly desired.  
• PBPK modeling knowledge is a plus.

What we offer: 

• Industry competitive compensation
• Annual target bonus
• Stock options
• 401K plan
• Career advancement opportunities
• Monthly town halls to share business and scientific updates

Work Hard, Stay Well 

• Comprehensive medical, dental, and vision plans for employees and their dependents
• Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution
• Employee Assistance Program
• 10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave.
• Supplemental pay for Pregnancy Disability Leave
• Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care

Lifestyle

• Casual work environment
• Volunteer days off each year to spend time contributing to causes you care about
• Flexible work schedule
• Access to onsite gym
• Onsite space to store your bicycle (or surfboard) 

Have Fun! 

We believe in work/life balance and Fun is at the core of our Core Values.  In addition to department and company happy hours, we have regular company-wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day).

About Us: 

Neomorph is a venture backed biotechnology company solving critical problems in human health through the discovery and development of innovative new medicines against ‘undruggable targets’. Our team is comprised of industry leading experts in protein degradation and molecular glues who have a track record of ground-breaking discoveries in the field. We are committed to leadership in advancing the science and technology of molecular glue drug discovery, while prosecuting a pipeline of projects through clinical development. Our patient-first, science-driven approach is complemented by our dedication to a supportive and collaborative work environment. 

Neomorph is headquartered in San Diego, California, and has a key collaboration with the Center for Protein Degradation at the Dana-Farber Cancer Institute. 

Neomorph is committed to pursuing and hiring a diverse workforce and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of any characteristic protected by applicable federal, state or local law.

Notice to agencies: Neomorph will not accept unsolicited assistance from recruiting/search agencies for this employment opportunity. Please, no phone calls or emails. All resumes submitted by recruiting or search agencies to any employee at Neomorph via email, the Internet or in any form and/or method without a valid written search/recruitment agreement in place for this position will be deemed the sole property of Neomorph. No fee will be paid in the event the candidate is hired by Neomorph as a result of the referral or through other means.