We are seeking a talented medicinal chemist with excellent communication and collaboration skills and demonstrated experience working collaboratively in multi-disciplinary teams (spanning chemistry, biology, pharmacology, DMPK and toxicology). The successful candidate will lead from the lab and be a key driver of medicinal chemistry strategy and a critical contributor to projects, (with opportunities for project leadership), from inception through clinical candidate nomination. Applicants should be well versed in drug design concepts and have demonstrated individual and team impact on small molecule Hit to Lead and Lead Optimization efforts.

Role and responsibility

Collaborate with a senior Project Lead to formulate medicinal chemistry strategy and then independently manage the execution of this strategy including overseeing the internal and external chemistry teams. Projects in scope for this role will typically initiate at the transition from hit validation into hit to lead and progress to Development Candidate (DC) nomination.

• Contribute intellectually to chemistry project teams through data analysis, compound designs to address key multiparametric optimization challenges in addition to synthetic troubleshooting and optimization
• Leading from the bench – candidate will spend a portion of their time in the lab enabling and impacting project progression by developing challenging chemistry that can be transferred to external partners
• Manage external chemistry CRO resources
• Selects compounds for progression through the assay flowchart
• Work within mandated laboratory safety policies and maintain an electronic notebook to company standards.
• Contribute to patent filings, publications and presentations
• Collaborate with other line functions (biology, pharmacology, biochemistry, DMPK, etc) to design key experiments and to set project goals and strategies.
• Present project updates to key stakeholders including chemistry and company leadership

Required qualifications: 

• PhD in organic chemistry, or related field with 5+ years, MS with 8+ years or BS with 11+ years of relevant experience
• High level of creativity and productivity with strong synthetic problem-solving skills, synthetic methods and reactions mechanisms are required.
• Demonstrated expertise in modern methods and technologies in synthetic organic chemistry
• Demonstrated expertise in drug design to improve compound affinity, drug-likeness and DMPK/safety properties
• Familiarity with structure and ligand based drug design concepts
• Excellent communication skills
• Collaborative mindset

What we offer: 

• Industry competitive compensation
• Annual target bonus
• Stock options
• 401K plan
• Career advancement opportunities
• Monthly town halls to share business and scientific updates

Work Hard, Stay Well 

• Comprehensive medical, dental, and vision plans for employees and their dependents
• Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution
• Employee Assistance Program
• 10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave.
• Supplemental pay for Pregnancy Disability Leave
• Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care

Lifestyle

• Casual work environment
• Volunteer days off each year to spend time contributing to causes you care about
• Flexible work schedule
• Access to onsite gym
• Onsite space to store your bicycle (or surfboard) 

Have Fun! 

We believe in work/life balance and Fun is at the core of our Core Values.  In addition to department and company happy hours, we have regular company-wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day).

About Us: 

Neomorph is a venture backed biotechnology company solving critical problems in human health through the discovery and development of innovative new medicines against ‘undruggable targets’. Our team is comprised of industry leading experts in protein degradation and molecular glues who have a track record of ground-breaking discoveries in the field. We are committed to leadership in advancing the science and technology of molecular glue drug discovery, while prosecuting a pipeline of projects through clinical development. Our patient-first, science-driven approach is complemented by our dedication to a supportive and collaborative work environment. 

Neomorph is headquartered in San Diego, California.

Neomorph is committed to pursuing and hiring a diverse workforce and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of any characteristic protected by applicable federal, state or local law.

Notice to agencies: Neomorph will not accept unsolicited assistance from recruiting/search agencies for this employment opportunity. Please, no phone calls or emails. All resumes submitted by recruiting or search agencies to any employee at Neomorph via email, the Internet or in any form and/or method without a valid written search/recruitment agreement in place for this position will be deemed the sole property of Neomorph. No fee will be paid in the event the candidate is hired by Neomorph as a result of the referral or through other means.

The role is highly cross-functional and will work closely with Research Biology, Clinical Development/Clinical Operations, Data Sciences (Bioinformatics), and external collaborators/CROs. The ideal candidate has deep biology expertise in human disease biology, strong translational research experience, and the ability to operate effectively in a fast-paced, small-company environment.

Key Responsibilities

• Identify and validate development opportunities across the Neomorph pipeline in oncology and non-oncology.
• Design and oversee preclinical translational studies using in vitro and in vivo models (e.g., cell lines, organoids, xenografts, PDX models, ex vivo patient samples) and relevant molecular profiling platforms.
• Support indication expansion, combination strategies, dose selection, and dose schedule optimization through translational research.
• Stay current with the target’s biology, competitors, and emerging therapeutic mechanisms.
• Oversee external vendors, academic collaborators, and CROs.
• Collaborate with Bioinformatics/Biometrics to analyze and interpret translational datasets, including genomics, transcriptomics, proteomics, pharmacodynamic, and clinical outcome data.
• Contribute to regulatory documents, including INDs, clinical protocols, investigator brochures, annual reports, and responses to health authority questions.
• Present translational data and strategy to internal leadership and external partners.

• Biomarker discovery, development, and clinical implementation:
  • Develop and implement predictive biomarkers to support patient selection for Neomorph’s clinical studies.
  • Develop and implement pharmacodynamic biomarkers for Neomorph’s clinical studies. Clinical biomarker strategies include tissue and blood-based assays, e.g., LC-MS, IHC/IF, NGS, ELISA, and other potential biomarker readouts.
  • Oversee external vendors and CROs for clinical biomarker test development, validation, and analyses.
  • Partner with Clinical Development/Operations to integrate biomarkers into Phase 1/2 clinical protocols and to implement biospecimen collection, processing, shipment, testing, and data analysis.

Qualifications

• PhD, MD, MD/PhD, PharmD, or equivalent advanced degree in biology or genomics, molecular biology, translational medicine, or a related discipline.
• Sr. Scientist: 5+ years of relevant experience; Principal Scientist: 8+ years of relevant experience; or Director: 12+ years of relevant experience in drug discovery, translational research, and clinical biomarker development, with biotech/pharma experience preferred.
• Experience supporting programs in IND-enabling, Phase 1, and/or Phase 2 clinical development.

• Experience with in vitro and in vivo models (e.g., cell lines, organoids, xenografts, PDX models, ex vivo patient samples) and relevant molecular profiling.
• Hands-on experience with biomarker assays such as e.g., LC-MS, IHC, IF, ctDNA, NGS, RNA-seq, flow cytometry, proteomics, single-cell methods, etc.

• Demonstrated ability to translate preclinical biology into clinical biomarker and patient-selection strategies.

• Experience managing CROs, academic collaborations, and external translational vendors.
• Strong data interpretation skills and ability to integrate complex biological, pharmacodynamic, and clinical datasets.
• Excellent written and verbal communication skills.
• Ability to work independently, prioritize effectively, and thrive in a, fast-moving biotech environment.

Preferred Experience

• Experience in oncology and at least one non-oncology disease area is a plus.
• Experience with PD biomarker development and predictive biomarker strategies for patient enrichment.
• Experience with targeted protein degradation is a plus.
• Prior experience contributing to IND submissions or early clinical oncology protocols.
• Familiarity with companion diagnostic or exploratory diagnostic development.

Key Competencies

• Scientific leadership and strategic thinking.
• Translational and clinical-development mindset.
• Strong human biology expertise.
• Cross-functional collaboration.
• Vendor and project management.
• Clear communication with scientific and non-scientific stakeholders.
• Hands-on problem solving in a small-company environment.
• Ability to balance scientific rigor with practical execution. 

What we offer: 

• Industry-competitive compensation
• Annual target bonus
• Stock options
• 401K plan
• Career advancement opportunities
• Monthly town halls to share business and scientific updates

Work Hard, Stay Well 

• Comprehensive medical, dental, and vision plans for employees and their dependents
• Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution
• Employee Assistance Program
• 10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave.
• Supplemental pay for Pregnancy Disability Leave
• Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care

Lifestyle

• Casual work environment
• Volunteer days off each year to spend time contributing to causes you care about
• Flexible work schedule
• Access to onsite gym
• Onsite space to store your bicycle (or surfboard) 

Have Fun! 

We believe in work/life balance and Fun is at the core of our Core Values.  In addition to department and company happy hours, we have regular company-wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day).

About Us: 

Neomorph is a venture backed biotechnology company solving critical problems in human health through the discovery and development of innovative new medicines against ‘undruggable targets’. Our team is comprised of industry leading experts in protein degradation and molecular glues who have a track record of ground-breaking discoveries in the field. We are committed to leadership in advancing the science and technology of molecular glue drug discovery, while prosecuting a pipeline of projects through clinical development. Our patient-first, science-driven approach is complemented by our dedication to a supportive and collaborative work environment. 

Neomorph is headquartered in San Diego, California.

Neomorph is committed to pursuing and hiring a diverse workforce and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of any characteristic protected by applicable federal, state or local law.

Notice to agencies: Neomorph will not accept unsolicited assistance from recruiting/search agencies for this employment opportunity. Please, no phone calls or emails. All resumes submitted by recruiting or search agencies to any employee at Neomorph via email, the Internet or in any form and/or method without a valid written search/recruitment agreement in place for this position will be deemed the sole property of Neomorph. No fee will be paid in the event the candidate is hired by Neomorph as a result of the referral or through other means.

We are seeking a Scientist to join our Lead Discovery team with a focus on cell-based high-throughput screening (HTS). This position may be filled at the Scientist I or Scientist II level based on the selected candidate’s education, experience, technical depth, demonstrated accomplishments, and ability to operate independently. The successful candidate will contribute directly to small-molecule drug discovery programs by developing, executing, and analyzing robust, miniaturized cell-based assays in a fast-paced biotechnology environment.

Key Responsibilities

• Design, develop, optimize, and execute robust, reproducible cell-based assays to support high-throughput screening, hit confirmation, and hit-to-lead campaigns.
• Culture, maintain, characterize, and bank mammalian cell lines used in screening and assay-development workflows.
• Apply assay miniaturization, automation, and statistical quality-control principles to generate reliable screening data in 96-, 384-, and 1536-well formats.
• Collaborate closely with biology, chemistry, automation, compound management, and data teams to plan and execute screening campaigns.
• Troubleshoot assay performance, cellular readouts, liquid-handling methods, and sources of screening variability.
• Analyze, interpret, and clearly communicate experimental and screening results in internal meetings, written reports, and electronic systems.
• Maintain complete and timely documentation in electronic laboratory notebooks and other applicable data-management systems.
• Contribute to the development, standardization, and continuous improvement of screening workflows, assay-quality practices, and automation processes.
• Support assay transfer, validation, and implementation on automated HTS platforms.
• Perform other duties as assigned.

Level-Specific Expectations

Scientist I

• Develop technical proficiency in cell-based assay development, mammalian cell culture, and HTS operations while contributing independent thought and scientific creativity.
• Work on problems of moderate scope, using established procedures and identifiable data factors to determine appropriate actions.
• Perform routine work with general instruction and complete new or unfamiliar assignments with more detailed guidance.
• Independently develop and optimize assays and solve a wide range of difficult technical problems using imaginative and practical approaches.
• Work across projects of diverse scopes, evaluate relevant data factors, and select methods and techniques within generally defined practices.
• Operate independently on routine work and receive general directions on new assignments.
  • Multi-mode plate readers such as EnVision, PHERAstar, and ClarioStar for luminescence, fluorescence, absorbance, and time-resolved fluorescence.
  • Flow cytometry platforms, including Cytek Biosciences systems, for cell-based screening applications.
  • Echo acoustic dispensers for low-volume, non-contact liquid dispensing.
  • LGR Precise Drop or comparable low-volume reagent and cell-dispensing systems.
  • Tecan Freedom EVO/Fluent, Hamilton Microlab STAR/NIMBUS, or Beckman Biomek platforms for pipetting, dilution, plate manipulation, and method optimization.
  • Compound storage and retrieval systems, automated incubators, robotic plate handling, barcode tracking, and LIMS integration.
  • Automated screening workflows connecting assay requests, compound plates, liquid handling, detection, and data systems.
  • Cell-based and biochemical assay development, miniaturization, validation, statistical analysis, and quality-control assessment.
  • Primary and secondary screening campaign execution, hit identification, data review, and comprehensive screening documentation.

Scientist II

Programs and systems may include:

• Detection Instrumentation

• Automated Liquid Handling Systems

• Laboratory Automation Infrastructure

• Assay Development and Screening Operations

Qualifications

• Degree in Biology, Pharmacology, Biochemistry, Cell Biology, or a related scientific discipline, or an equivalent combination of education and relevant industry experience.
• Level will be determined based on the candidate’s qualifications and alignment with the following general experience guidelines: Scientist I— PhD with relevant experience, MS with 8+ years of related experience or BS with 12+ years of relevant industry experience; Scientist II— PhD with 2 years of related experience, MS with 10+ years of relevant experience, or BS with 15+ years of relevant industry experience.
• Hands-on experience with mammalian cell culture, including maintenance, transfection or transduction, and banking of multiple cell lines.
• Experience developing or running quantitative cell-based assays using luminescence, fluorescence, time-resolved fluorescence, flow cytometry, high-content imaging, or related readouts.
• Understanding of assay-performance and screening-quality metrics such as Z', signal-to-background, coefficient of variation, and concentration-response analysis.
• Experience with laboratory automation, liquid handlers, plate readers, dispensers, or automated HTS workflows appropriate to career level.
• Strong organizational skills, attention to detail, scientific judgment, and ability to manage multiple workflows and timelines.
• Collaborative approach with strong verbal, written, and data-presentation skills.

Preferred Qualifications

• Experience transferring, validating, and implementing assays on automated HTS platforms.
• Experience with 384- and/or 1536-well assay formats and low-volume liquid handling.
• Familiarity with high-content imaging, multiplexed readouts, or flow cytometry-based screening.
• Experience generating stable cell lines or using inducible expression systems.
• Background in molecular biology techniques such as cloning, CRISPR editing, or viral-vector production.

What we offer: 

• Industry competitive compensation
• Annual target bonus
• Stock options
• 401K plan
• Career advancement opportunities
• Monthly town halls to share business and scientific updates

Work Hard, Stay Well 

• Comprehensive medical, dental, and vision plans for employees and their dependents
• Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution
• Employee Assistance Program
• 10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave.
• Supplemental pay for Pregnancy Disability Leave
• Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care

Lifestyle

• Casual work environment
• Volunteer days off each year to spend time contributing to causes you care about
• Flexible work schedule
• Access to onsite gym
• Onsite space to store your bicycle (or surfboard) 

Have Fun! 

We believe in work/life balance and Fun is at the core of our Core Values.  In addition to department and company happy hours, we have regular company-wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day).

About Us: 

Neomorph is a venture backed biotechnology company solving critical problems in human health through the discovery and development of innovative new medicines against ‘undruggable targets’. Our team is comprised of industry leading experts in protein degradation and molecular glues who have a track record of ground-breaking discoveries in the field. We are committed to leadership in advancing the science and technology of molecular glue drug discovery, while prosecuting a pipeline of projects through clinical development. Our patient-first, science-driven approach is complemented by our dedication to a supportive and collaborative work environment. 

Neomorph is headquartered in San Diego, California.

Neomorph is committed to pursuing and hiring a diverse workforce and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of any characteristic protected by applicable federal, state or local law.

Notice to agencies: Neomorph will not accept unsolicited assistance from recruiting/search agencies for this employment opportunity. Please, no phone calls or emails. All resumes submitted by recruiting or search agencies to any employee at Neomorph via email, the Internet or in any form and/or method without a valid written search/recruitment agreement in place for this position will be deemed the sole property of Neomorph. No fee will be paid in the event the candidate is hired by Neomorph as a result of the referral or through other means.

Neomorph is seeking an experienced drug discovery biologist with extensive experience participating in or leading programs through strategic, intellectual, and experimental contributions. The role will be critically involved in supporting Neomorph's growing pipeline by driving advancement of programs from early discovery through IND-enabling studies. The successful applicant will proactively collaborate across line functions to establish overarching project strategies and advance programs towards data-driven go/no go decisions.

Key Responsibilities

Participate in and/or lead cross-functional teams to advance therapeutic candidates from early discovery to clinical development through strategic prioritization, effective interdisciplinary collaboration, and efficient technical execution.

Lead from the bench - independently lead the development and execution of project-specific cellular assays to define target mechanism of action, assess markers of pharmacodynamic response, and identify relevant patient populations.

Design and implement effective triaging strategies to support SAR advancement and refinement of target compound profiles based on deep mechanistic understanding of underlying biology.

Generate and lead new target nomination/identification/validation activities that leverage unique aspects of the molecular glue degrader modality.

Anticipate, evaluate, and strategically respond to changes in scientific, competitive, or regulatory landscape.

Effectively communicate scientific advancements, strategic shifts, and risk assessments to project stakeholders.

Contribute to Neomorph's culture of scientific rigor, open collaboration, and continuous learning by openly sharing expertise and providing mentorship to junior scientists.

Required Qualifications

• PhD with 6+ years, MS with 9+ years, or BS with 11+ years of industry experience
• Track record of strategic, creative, and effective advancement of preclinical drug discovery programs supported by robust data packages
• Demonstrated experience independently developing and implementing robust, reproducible SAR-enabling assay cascades supporting drug discovery programs
• Experience successfully managing a team directing and coaching employees.
• Experience participating in and/or leading cross-functional teams
• Excellent verbal and written communication and interpersonal skills
• Desire and capacity to participate in a dynamic and fast-paced research setting
• Desire and capacity to work collaboratively as part of a multidisciplinary team

Preferred Qualifications

• Experience with targeted protein degradation
• Experience managing teams of one or more associate scientists

What we offer: 

• Industry competitive compensation
• Annual target bonus
• Stock options
• 401K plan
• Career advancement opportunities
• Monthly town halls to share business and scientific updates

Work Hard, Stay Well 

• Comprehensive medical, dental, and vision plans for employees and their dependents
• Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution
• Employee Assistance Program
• 10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave.
• Supplemental pay for Pregnancy Disability Leave
• Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care

Lifestyle

• Casual work environment
• Volunteer days off each year to spend time contributing to causes you care about
• Flexible work schedule
• Access to onsite gym
• Onsite space to store your bicycle (or surfboard) 

Have Fun! 

We believe in work/life balance and Fun is at the core of our Core Values.  In addition to department and company happy hours, we have regular company-wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day).

About Us: 

Neomorph is a venture backed biotechnology company solving critical problems in human health through the discovery and development of innovative new medicines against ‘undruggable targets’. Our team is comprised of industry leading experts in protein degradation and molecular glues who have a track record of ground-breaking discoveries in the field. We are committed to leadership in advancing the science and technology of molecular glue drug discovery, while prosecuting a pipeline of projects through clinical development. Our patient-first, science-driven approach is complemented by our dedication to a supportive and collaborative work environment. 

Neomorph is headquartered in San Diego, California.

Neomorph is committed to pursuing and hiring a diverse workforce and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of any characteristic protected by applicable federal, state or local law.

Notice to agencies: Neomorph will not accept unsolicited assistance from recruiting/search agencies for this employment opportunity. Please, no phone calls or emails. All resumes submitted by recruiting or search agencies to any employee at Neomorph via email, the Internet or in any form and/or method without a valid written search/recruitment agreement in place for this position will be deemed the sole property of Neomorph. No fee will be paid in the event the candidate is hired by Neomorph as a result of the referral or through other means.

Length of contract: 6 months with potential for extension or conversion to full-time

Pay: $26-$42 per hour; this is a W-2 position.

We’re looking for a hands‑on, service‑oriented Operations Associate to support Neomorph’s laboratory operations. In this role, you’ll work cross‑functionally with our research team, Facilities partners, and external vendors to maintain a safe, efficient, and well‑organized working environment. You’ll be at the heart of daily lab operations—ensuring scientists have what they need, when they need it, so they can focus on advancing high‑quality, translational science. 

You are collaborative, dependable, and highly organized, with a passion for developing and improving processes that drive operational excellence while upholding the highest standards of safety and compliance. You manage your time well, communicate clearly, and take pride in anticipating needs and solving problems in real time. Whether you’re supporting lab workflows, responding to researcher requests, or ensuring the lab remains clean, compliant, and inspection‑ready, you bring a proactive mindset and a strong sense of ownership to everything you do. 

If you enjoy meaningful, hands‑on work, thrive in fast‑paced laboratory and operational environments, and are motivated by enabling great science through behind‑the‑scenes excellence, this role offers the chance to make an immediate and tangible impact. 

Responsibilities 

• Provide onsite laboratory operations support 24/7, including some holidays
• Independently support day-to-day laboratory and operations activities with minimal supervision
• Prepare, organize, label, and manage materials, samples, and equipment in accordance with SOPs
• Perform routine equipment setup, basic calibration, preventative maintenance, and first-level troubleshooting
• Receive, inspect, document, and store incoming materials in compliance with quality and safety standards
• Identify process inefficiencies and recommend improvements to lab and operations workflows

• Support ongoing laboratory operations with an emphasis on ordering, receiving, stocking, storage and distribution of all lab consumables, media, reagents, equipment, supplies, lab gases and any other inventory item(s) related to the operation of the laboratory.

• Triage and respond to researchers’ requests for assistance in a timely fashion 

• Ensure that the safety protocols in place are being followed and keep chemical and biological waste storage in compliance.
• Serve as a reliable point of contact between lab staff, operations, and leadership
• Ensure the lab is well maintained, exceeds safety standards, and remains clean and orderly
• Operate the autoclave and glasswasher to ensure that there is a steady supply of clean glassware available for end-user use
• Waste Disposal: Coordinate safe and compliant disposal of hazardous and biological waste

 Required qualifications:

• Associate's degree in a scientific discipline (i.e. Biology, Chemistry, Engineering)
• 1 – 3 years of experience working in a laboratory or operations support, preferably in biotech, pharma, or another scientific environment.
• A basic understanding of the processes and protocols required in a scientific research organization
• Familiarity with basic lab operations, safety procedures, or hazardous waste handling.
• Proficiency in Excel, Word, PowerPoint, and Outlook is required
• Proactive problem-solver with a willingness to learn new systems and processes.
• Ability to prioritize tasks and manage competing demands in a fast-paced environment
• Dependable, self-directed, and accountable for assigned responsibilities
• Willingness to adapt to evolving operational needs, technologies, and procedures
• Strong organizational skills with the ability to manage multiple tasks and priorities.
• Excellent communication and customer service mindset; comfortable supporting a variety of cross-functional teams.
• Basic understanding of OSHA and general EHS concepts.

Physical & Environmental Requirements

• Ability to lift, carry, push, and pull items weighing up to 50 pounds
• Ability to stand, walk, bend, and perform repetitive motions for extended periods in operational environments
• Comfortable working in laboratory and warehouse settings with adherence to PPE and safety requirements

Responsibilities

• Help drive and execute Neomorph’s immunology discovery strategy in alignment with the company’s overall R&D priorities.
• Accelerate the immunology pipeline and strategy based on scientific rationale, therapeutic potential, and unmet need.
• Work collaboratively with internal chemistry and molecular sciences teams to effectively prosecute immunology drug discovery programs.
• Think clinically and strategically to ensure program direction aligns with future patient population needs and translational opportunities.
• Present findings and strategic recommendations to cross-functional teams and leadership.

Qualifications

• Ph.D. in Immunology, Microbiology, Molecular Biology, or a related field with 10 + years of relevant experience, MS with 13+ years or BS with 16+ years of relevant experience
• Proven track record leading immunology small molecule drug discovery programs
• Broad and deep knowledge of adaptive and innate immunity and translation to human disease

• Experience in functional assay development and target validation for immunology targets
• Ability to evaluate new targets, design experimental strategies, and guide projects toward key decision points
• Excellent communication and collaboration skills, with a track record of working cross-functionally to advance research goals
• Candidates from academia must demonstrate experience translating fundamental research into therapeutic concepts and leading complex, goal-oriented scientific programs
• Candidates with prior experience working in the targeted protein degradation space are strongly preferred

What we offer: 

• Industry competitive compensation
• Annual target bonus
• Stock options
• 401K plan
• Career advancement opportunities
• Monthly town halls to share business and scientific updates

Work Hard, Stay Well 

• Comprehensive medical, dental, and vision plans for employees and their dependents
• Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution
• Employee Assistance Program
• 10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave.
• Supplemental pay for Pregnancy Disability Leave
• Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care

Lifestyle

• Casual work environment
• Volunteer days off each year to spend time contributing to causes you care about
• Flexible work schedule
• Access to onsite gym
• Onsite space to store your bicycle (or surfboard) 

Have Fun! 

We believe in work/life balance and Fun is at the core of our Core Values.  In addition to department and company happy hours, we have regular company-wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day).

About Us: 

Neomorph is a venture backed biotechnology company solving critical problems in human health through the discovery and development of innovative new medicines against ‘undruggable targets’. Our team is comprised of industry leading experts in protein degradation and molecular glues who have a track record of ground-breaking discoveries in the field. We are committed to leadership in advancing the science and technology of molecular glue drug discovery, while prosecuting a pipeline of projects through clinical development. Our patient-first, science-driven approach is complemented by our dedication to a supportive and collaborative work environment. 

Neomorph is headquartered in San Diego, California.

Neomorph is committed to pursuing and hiring a diverse workforce and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of any characteristic protected by applicable federal, state or local law.

Notice to agencies: Neomorph will not accept unsolicited assistance from recruiting/search agencies for this employment opportunity. Please, no phone calls or emails. All resumes submitted by recruiting or search agencies to any employee at Neomorph via email, the Internet or in any form and/or method without a valid written search/recruitment agreement in place for this position will be deemed the sole property of Neomorph. No fee will be paid in the event the candidate is hired by Neomorph as a result of the referral or through other means.

Reporting to the VP of Clinical Operations, the CTM partners with cross-functional teams and external vendors to advance the company’s clinical programs. This role is expected to provide hands-on oversight of early-phase oncology studies, including complex site activation, enrollment, safety, and data-delivery activities. This is a hybrid position based at our site in San Diego.

Key Responsibilities

Clinical Trial Management

• Lead the day-to-day operational management of assigned clinical trials from study start-up through close-out, with particular focus on early-phase oncology development.
• Develop and maintain integrated study timelines, operational plans, trackers, and key performance indicators to ensure milestones are achieved.
• Coordinate cross-functional study activities across clinical development, clinical operations, data management, biostatistics, regulatory, pharmacovigilance/safety, quality, CMC, translational, and other relevant functions.
• Identify operational risks, escalate issues appropriately, and implement mitigation and contingency plans to protect study timelines, quality, and patient safety.
• Support operational planning for dose-escalation and dose-expansion cohorts, including readiness for safety review and dose-escalation decision meetings, as applicable.

CRO and Vendor Oversight

• Manage and oversee CROs, clinical vendors, and consultants, with clear accountability for scope, timelines, deliverables, quality, and budget.
• Monitor vendor performance using agreed metrics and governance processes; drive timely resolution of performance or quality issues.
• Participate in vendor identification and selection, RFP processes, bid defenses, scope-of-work development, and contract review.

Site Management and Monitoring Oversight

• Oversee site feasibility, selection, activation, initiation, monitoring, and close-out activities conducted by CROs or monitors.
• Review monitoring reports, enrollment metrics, site performance data, protocol compliance, and quality trends; ensure follow-up actions are completed.
• Develop and support site engagement and enrollment strategies appropriate for competitive oncology indications and patient populations.
• Partner with cross-functional teams and vendors to address site-level operational barriers, including recruitment, retention, sample logistics, and study drug supply.

Study Start-Up and Regulatory Support

• Drive or support study start-up activities, including site feasibility, essential document collection, investigator meeting planning, and activation readiness.
• Collaborate with Regulatory and CRO partners on submission-related activities, responses, and documentation for applicable health authorities and ethics committees/IRBs.

Budget and Financial Oversight

• Manage assigned study budgets, forecasts, accrual inputs, and clinical trial expenditures in partnership with Finance and Clinical Operations leadership.
• Review CRO and vendor invoices for accuracy, milestone achievement, and alignment with contractual terms; identify and resolve discrepancies.

Compliance and Quality

• Ensure clinical trials are conducted in compliance with ICH-GCP, applicable global regulatory requirements, protocol requirements, and company SOPs.
• Support inspection and audit readiness, including timely identification, documentation, escalation, and remediation of quality issues.

Cross-Functional Collaboration & Communication

• Partner closely with internal stakeholders to ensure operational plans remain aligned with clinical development objectives and program priorities.
• Provide clear, concise study status updates, risk assessments, and decision points to the VP of Clinical Operations and other senior leaders.
• Contribute to the development and continuous improvement of clinical operations processes, tools, and infrastructure as the company grows.

Travel Requirements

• Up to 20%, including travel to investigator meetings, study sites, vendor meetings, or other clinical activities as needed.

Qualifications

• Bachelor’s degree in life sciences, nursing, public health, or related field required.
• Advanced degree (MS, MPH, PharmD, or PhD, or equivalent) preferred.

Experience

• 7+ years of progressive experience in clinical research or clinical operations within biotech, pharmaceutical, or CRO environments.
• Demonstrated experience managing Phase 1 and/or other early-phase clinical trials; study start-up and close-out experience strongly preferred; oncology trial experience strongly preferred.
• Hands-on experience leading clinical trial execution balancing strategic oversight with detailed operational follow-through.
• Proven experience managing CROs and external vendors including performance oversight, issue escalation, and budget accountability.
• Working knowledge of oncology trial operations, including complex eligibility criteria, safety-intensive studies, dose-escalation/expansion designs, and time-sensitive site and data workflows.
• Strong understanding of ICH-GCP, FDA requirements, and applicable global clinical trial regulations and processes.
• Experience partnering with CMC and supply-chain stakeholders to support clinical supply readiness and continuity, including experience with clinical trial supply projections.
• Experience partnering with clinical translation and pharmacology stakeholders to support clinical trial PK/PD sample collection, reconciliation, and trouble-shooting.
• Strong clinical trial financial management skills, including budget tracking, forecasting, accruals, invoice review, and change-order management.
• Excellent project management, organizational, problem-solving, and communication skills, with the ability to manage multiple priorities in a fast-paced environment.
• Ability to build effective relationships across functions and with external partners, influence without direct authority, and communicate clearly with senior leadership.
• Experience helping build, scale, or optimize clinical operations processes and infrastructure is preferred.
• Experience using AI to help create efficiencies and scale workload is a plus.

What we offer: 

• Industry competitive compensation
• Annual target bonus
• Stock options
• 401K plan
• Career advancement opportunities
• Monthly town halls to share business and scientific updates

Work Hard, Stay Well 

• Comprehensive medical, dental, and vision plans for employees and their dependents
• Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution
• Employee Assistance Program
• 10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave.
• Supplemental pay for Pregnancy Disability Leave
• Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care

Lifestyle

• Casual work environment
• Volunteer days off each year to spend time contributing to causes you care about
• Flexible work schedule
• Access to onsite gym
• Onsite space to store your bicycle (or surfboard) 

Have Fun! 

We believe in work/life balance and Fun is at the core of our Core Values.  In addition to department and company happy hours, we have regular company-wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day).

About Us: 

Neomorph is a venture backed biotechnology company solving critical problems in human health through the discovery and development of innovative new medicines against ‘undruggable targets’. Our team is comprised of industry leading experts in protein degradation and molecular glues who have a track record of ground-breaking discoveries in the field. We are committed to leadership in advancing the science and technology of molecular glue drug discovery, while prosecuting a pipeline of projects through clinical development. Our patient-first, science-driven approach is complemented by our dedication to a supportive and collaborative work environment. 

Neomorph is headquartered in San Diego, California.

Neomorph is committed to pursuing and hiring a diverse workforce and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of any characteristic protected by applicable federal, state or local law.

Notice to agencies: Neomorph will not accept unsolicited assistance from recruiting/search agencies for this employment opportunity. Please, no phone calls or emails. All resumes submitted by recruiting or search agencies to any employee at Neomorph via email, the Internet or in any form and/or method without a valid written search/recruitment agreement in place for this position will be deemed the sole property of Neomorph. No fee will be paid in the event the candidate is hired by Neomorph as a result of the referral or through other means.