Neomorph is seeking a highly motivated and accomplished Senior Scientist to advance our molecular glue discovery platform and early target discovery efforts in targeted protein degradation.

The successful candidate will independently develop and execute innovative experimental strategies to identify and validate novel targets, establish and expand molecular glue discovery capabilities, and elucidate the mechanisms of action of small-molecule molecular glues. This individual will play a central role in translating early discovery findings into new pipeline opportunities and will collaborate closely with multidisciplinary teams to advance platform technologies and guide data-driven research decisions.

Key Responsibilities

• Independently design and execute experimental strategies to identify, prioritize, and validate novel targets using chemical and/or genetic approaches.
• Develop, optimize, and implement robust cell-based assays to characterize molecular glue activity, including target degradation, ternary complex formation, and mechanism of action.
• Integrate and critically interpret literature and diverse discovery datasets, including high-throughput screening, proteomics, and genetic perturbation studies, to generate hypotheses and guide target discovery and validation activities.
• Develop and implement innovative assay technologies and experimental approaches that expand the capabilities, efficiency, and scope of Neomorph's molecular glue discovery platform.
• Independently troubleshoot complex scientific and technical challenges, identify critical knowledge gaps, and develop practical strategies to advance research objectives.
• Communicate scientific findings, recommendations, and research strategies effectively to multidisciplinary teams, contributing to decisions regarding platform development and the advancement of new pipeline programs.

Required Qualifications

• PhD with 5 years, MS with 8 years, or BS with 11 years of relevant experience
• Demonstrated expertise in developing, optimizing, and implementing cell-based assays to investigate small-molecule activity and mechanism of action.
• Strong understanding of targeted protein degradation, molecular glue biology, or closely related areas of chemical biology and small-molecule mechanism-of-action research.
• Demonstrated ability to independently formulate hypotheses, design rigorous experimental strategies, critically analyze complex datasets, and solve challenging scientific problems.
• Experience developing and implementing quantitative degradation and protein interaction assays, including HiBiT, NanoBiT, NanoBRET, or related methodologies.
• Experience with CRISPR-based genome editing, genetic perturbation approaches, and the generation of engineered reporter cell lines.
• Experience applying molecular and cellular biology techniques, including molecular cloning, genetic manipulation, and the generation and characterization of engineered cell lines.
• Demonstrated ability to develop and communicate experimental plans to evaluate novel biological targets and advance early drug discovery research.
• Excellent scientific communication, organizational, and interpersonal skills, with the ability to collaborate effectively across multidisciplinary research teams.
• Strong scientific curiosity, creativity, and initiative, with the ability to independently drive research activities in a dynamic drug discovery environment.

Preferred Qualifications

• Direct experience with molecular glue degraders, PROTACs, or other targeted protein degradation technologies.
• Understanding of E3 ubiquitin ligase biology, ubiquitin-proteasome system function, and molecular mechanisms underlying induced protein degradation.
• Experience developing or implementing high-throughput screening assays and associated automation technologies.
• Demonstrated experience independently advancing early-stage drug discovery or platform development projects through critical scientific milestones.

What we offer: 

• Industry-competitive compensation
• Annual target bonus
• Stock options
• 401K plan
• Career advancement opportunities
• Monthly town halls to share business and scientific updates

Work Hard, Stay Well 

• Comprehensive medical, dental, and vision plans for employees and their dependents
• Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution
• Employee Assistance Program
• 10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave.
• Supplemental pay for Pregnancy Disability Leave
• Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care

Lifestyle

• Casual work environment
• Volunteer days off each year to spend time contributing to causes you care about
• Flexible work schedule
• Access to a state-of-the-art gym
• Onsite space to store your bicycle (or surfboard) 

Have Fun! 

We believe in work/life balance, and Fun is at the core of our Core Values.  In addition to department and company happy hours, we have regular company-wide and department lunches and social events (e.g., Padres games, summer picnic, holiday party, bring-your-kids-to-work day).

About Us: 

Neomorph is a venture-backed biotechnology company solving critical problems in human health through the discovery and development of innovative new medicines against ‘undruggable targets’. Our team is comprised of industry-leading experts in protein degradation and molecular glues who have a track record of ground-breaking discoveries in the field. We are committed to leadership in advancing the science and technology of molecular glue drug discovery, while prosecuting a pipeline of projects through clinical development. Our patient-first, science-driven approach is complemented by our dedication to a supportive and collaborative work environment. 

Neomorph is headquartered in San Diego, California.

Neomorph is committed to pursuing and hiring a diverse workforce and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of any characteristic protected by applicable federal, state or local law.

Notice to agencies: Neomorph will not accept unsolicited assistance from recruiting/search agencies for this employment opportunity. Please, no phone calls or emails. All resumes submitted by recruiting or search agencies to any employee at Neomorph via email, the Internet or in any form and/or method without a valid written search/recruitment agreement in place for this position will be deemed the sole property of Neomorph. No fee will be paid in the event the candidate is hired by Neomorph as a result of the referral or through other means.